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UNC2025 Chemical Structure

UNC2025

Cat. No. :BCP16544CAS No. :1429881-91-3Purity:98%
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Synonyms UNC-2025;UNC 2025
CAS Number 1429881-91-3
Purity 98%
M. Wt 476.66
Formula C28H40N6O
Storage Store at 4-8°C
UNC2025 was capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow. Kinome pro ling versus more than 300 kinases in vitro and cellular selectivity assessments demonstrate that 11 has similar subnanomolar activity against Flt3, an additional important target in acute myelogenous leukemia (AML), with pharmacologically useful selectivity versus other kinases examined.

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