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NVR 3-778 Chemical Structure

NVR 3-778

Data Sheet For research use only. Not for human use.
Cat. No. :BCP45472CAS No. :1445790-55-5Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1445790-55-5 Cat. No. BCP45472
Name NVR 3-778
Synonyms NVR3 778; NVR-3-778; K-89; K 89; K89; NVR3778; NVR 3778; NVR-3778;
SMILES C1CN(CCC1O)S(=O)(=O)C2=C(C=CC(=C2)C(=O)NC3=CC(=C(C(=C3)F)F)F)F
Chemical Name
Formula C18H16F4N2O4S M. Wt 432.39
Purity 98% Storage Store at 4-8°C
Description NVR 3-778 is the first capsid assembly modulator (CAM) that has demonstrated antiviral activity in hepatitis B virus (HBV)-infected patients. NVR 3-778 inhibited the generation of infectious HBV DNA-containing virus particles with a mean antiviral 50% effective concentration (EC50) of 0.40 µM in HepG2.2.15 cells. The antiviral profile of NVR 3-778 indicates pan-genotypic antiviral activity and a lack of cross-resistance with nucleos(t)ide inhibitors of HBV replication.
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