Vebicorvir New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP36939CAS No. ：2090064-66-5Purity：98%

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CAS No.	2090064-66-5	Cat. No.	BCP36939
Name	Vebicorvir
Synonyms	ABI H0731; ABI-H0731; ABIH0731; ABIH 0731; ABIH-0731; ABI H 0731; ABI H-0731;
SMILES	C1=CC=C2C(=C1)C(=O)NC3=C(S2(=O)=O)C=CC(=C3)C(=O)NCC4=CN=C(S4)C(F)(F)F
Chemical Name
Formula	C19H12F3N3O4S2	M. Wt	467.44
Purity	98%	Storage	Store at 4-8°C
Description	Vebicorvir is a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity. ABI-H0731 exhibited selective inhibition of HBV DNA replication (50% effective concentration [EC50] from 173 nM to 307 nM). Most importantly, ABI-H0731 suppressed covalently closed circular DNA (cccDNA) formation in two de novo infection models with EC50s from 1.84 μM to 7.3 μM. Mechanism-of-action studies indicated that ABI-H0731 is a direct-acting antiviral that targets HBV core protein, preventing HBV pregenomic RNA (pgRNA) encapsidation and subsequent DNA replication.