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Pitavastatin Chemical Structure

Pitavastatin

Cat. No. :BCP08462CAS No. :147511-69-1Purity:98%
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Synonyms NK-104;NK 104;NK104
CAS Number 147511-69-1
Purity 98%
M. Wt 421.46
Formula C25H24FNO4
Storage Store at 4-8°C
in vitro: Pitavastatin inhibited cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in a human liver cancer cell line (HepG2), which indicates that is 2.9 and 5.7 times as potent as simvastatin and atorvastatin, respectively. When the inhibitory activity interms of the ED50 was compared with that of simvastatin, pitavastatin showed a 3-fold stronger activity in the rat and 15-fold stronger activity in a guinea pig model.22 The inhibitory effect of pitavastatin on sterol synthesis is thought to be liver-selective. pitavastatin reduces total and phosphorylated tau levels in a cellular model of tauopathy, and in primary neuronal cultures. The decrease caused by pitavastatin is reversed by the addition of mevalonate, or geranylgeranyl pyrophosphate. The maturation of small G proteins, including RhoA was disrupted by pitavastatin, as was the activity of glycogen synthase kinase 3β (GSK3β), a major tau kinase. in vivo: Intravenous treatment with pitavastatin-incorporated nanoparti

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