Rosuvastatin
Data Sheet
For research use only. Not for human use.
Get Quotation Now* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
* Required Fields.
Please complete the form below and we will contact you shortly.
* Required Fields.
Please complete the form below and we will contact you shortly.
| CAS No. | 287714-41-4 | Cat. No. | BCP02356 |
| Name | Rosuvastatin | ||
| Synonyms | S-4522; S 4522; S4522; ZD 4522;ZD-4522;ZD4522;X-Plended;Crestor; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C22H28FN3O6S | M. Wt | 481.54 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | in vitro: Rosuvastatin is relatively hydrophilic and is highly selective for hepatic cells; its uptake is mediated by the liver-specific organic anion transporter OATP-C. Rosuvastatin is a high-affinity substrate for OATP-C with apparent association constant of 8.5 μM . Rosuvastatin inhibits cholesterol biosynthesis in rat liver isolated hepatocytes with IC50 of 1.12 nM. Rosuvastatin causes approximately 10 times greater increase of mRNA of LDL receptors than pravastatin . Rosuvastatin (100 μM) decreases the extent of U937 adhesion to TNF-α-stimulated HUVEC. Rosuvastatin inhibits the expressions of ICAM-1, MCP-1, IL-8, IL-6, and COX-2 mRNA and protein levels through inhibition of c-Jun N-terminal kinase and nuclear factor-kB in endothelial cells . in vivo: Rosuvastatin (3 mg/kg) daily administration for 14 days decreases plasma cholesterol levels by 26% in male beagle dogs with normal cholesterol levels. In cynomolgus monkeys, Rosuvastatin decreases plasma cholesterol levels by 22% . R | ||
Recommend Products
More >
-
-
Cerivastatin
Cat. No.：BCP24254
No.：145599-86-6
Product Details -
Simvastatin ammonium salt
Cat. No.：BCP14340
No.：139893-43-9
Product Details -
Pravastatin sodium
Cat. No.：BCP13374
No.：81131-70-6
Product Details -
Clinofibrate
Cat. No.：BCP13269
No.：30299-08-2
Product Details -
Tert-butyl rosuvastatin
Cat. No.：BCP13063
No.：355806-00-7
Product Details -
Fluvastatin sodium salt
Cat. No.：BCP12844
No.：93957-55-2
Product Details -
Rosuvastatin sodium
Cat. No.：BCP12749
No.：147098-18-8
Product Details -
-
Pitavastatin lactone
Cat. No.：BCP11656
No.：141750-63-2
Product Details -
Rosuvastatin Calcium
Cat. No.：BCP04131
No.：147098-20-2
Product Details -
Pitavastatin calcium
Cat. No.：BCP04793
No.：147526-32-7
Product Details -
Rosuvastatin methyl ester
Cat. No.：BCP04937
No.：147118-40-9
Product Details -
Pravastatin
Cat. No.：BCP21480
No.：81093-37-0
Product Details -
Simvastatin
Cat. No.：BCP06293
No.：79902-63-9
Product Details -
Cerivastatin Sodium
Cat. No.：BCP21297
No.：143201-11-0
Product Details -
Atorvastatin sodium
Cat. No.：BCP07413
No.：134523-01-6
Product Details -
Fluvastatin
Cat. No.：BCP08213
No.：93957-54-1
Product Details -
Pitavastatin
Cat. No.：BCP08462
No.：147511-69-1
Product Details -
Tags:Rosuvastatin supplier,Rosuvastatin purchase,Rosuvastatin manufacturer,Rosuvastatin distributor,Rosuvastatin cost,Rosuvastatin buy,Rosuvastatin for sale