Cathelicidin LL 37 (human) New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 154947-66-7 | Cat. No. | BCP30243 |
| Name | Cathelicidin LL 37 (human) | ||
| Synonyms | CAP-18;antibacterial peptide LL-37;Cathelicidin LL-37; LL 37; Peptide LL 37 (human gene FALL39 antibacterial); | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C205H340N60O53 | M. Wt | 4493.34 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | LL-37 is a synthetic form of a human antimicrobial peptide (37 amino acids), belonging to the cathelicidin family, with antimicrobial, anti-inflammatory, immunostimulating and potential antineoplastic activities. Upon intratumoral injection of the ropocamptide, this peptide increases p53 expression, and induces phosphatidylserine externalization, DNA fragmentation, cell cycle arrest and caspase-independent apoptosis-inducing factor (AIF)/ endonuclease G (EndoG)-mediated apoptotic cell death in susceptible cancer cells. This suppresses tumor cell proliferation. LL-37, a protein secreted by bone marrow cells, circulating leukocytes, and various epithelial tissues, plays a crucial role in the innate host immune defense via the regulation of leukocyte chemotaxis and cytokine production; it also promotes wound healing. | ||
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