Voreloxin

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP09159CAS No. ：175414-77-4Purity：98%

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CAS No.	175414-77-4	Cat. No.	BCP09159
Name	Voreloxin
Synonyms	AG-7352; SNS-595; Vosaroxin; AG 7352;
SMILES
Chemical Name
Formula	C18H19N5O4S	M. Wt	401.44
Purity	98%	Storage	Store at 4-8°C
Description	Voreloxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. As a result, inhibition of DNA replication, RNA and protein synthesis occurs, followed by cell cycle arrest at G2 phase and induced p53-independent apoptosis. This agent shows a favorable toxicity profile in several aspects: it does not generate reactive oxygen species, as do anthracyclines, reducing the risk of cardiotoxicity; it is not a P-glycoprotein (P-gp) substrate, and thereby evades the common mechanism for multidrug resistance; and it has limited distribution to normal tissues and a more chemically stable molecular structure.