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AR-R17779 Chemical Structure

AR-R17779

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP24016CAS No. ：178419-47-1Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 178419-47-1 Cat. No. BCP24016
Name AR-R17779
Synonyms AR-R-17779; AR-R 17779;
SMILES C1CN2CCC1C3(C2)CNC(=O)O3
Chemical Name
Formula C9H14N2O2 M. Wt 182.22
Purity 98% Storage Store at 4-8°C
Description AR-R17779 is a selective alpha7 nicotinic agonist (Ki values are 190 and 16000 nM for rat α7 and α4β2 receptors respectively). AR-R17779 improves learning and memory in rats. Treatment with AR-R17779 significantly reduced atherosclerotic plaque area and improved survival of mice. Treatment with AR-R17779 also suppressed abdominal aortic aneurysm formation. Quantitative RT-PCR of the aorta revealed that mRNA expression levels of interleukin-1β, interleukin-6 and NOX2 were significantly decreased in AR-R17779-treated mice compared with Ang II+HFD mice. AR-R17779 treatment also reduced blood pressure and serum lipid levels.
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