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CCMI Chemical Structure

CCMI

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP35052CAS No. ：917837-54-8Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 917837-54-8 Cat. No. BCP35052
Name CCMI
Synonyms AVL-3288; AVL 3288; AVL3288; XY-4083; XY 4083; XY4083; Anvylic-3288; UCI-4083; UCI4083; UCI 4083;
SMILES CC1=NOC(=C1)C(=CNC2=CC=C(C=C2)Cl)C(=O)NC3=CC=C(C=C3)Cl
Chemical Name
Formula C19H15Cl2N3O2 M. Wt 388.25
Purity 98% Storage Store at 4-8°C
Description CCMI is a first-in-class, orally available, small molecule, selective allosteric modulator of the alpha7 nicotinic acetylcholine receptor (α7 nAChR). AVL-3288 has shown preclinical efficacy in rat paradigms of attention and memory, including models of cognitive dysfunction1-3. AVL-3288 evokes positive modulation of acetylcholine (ACh)-induced EC5 currents (EC50 = 0.7 μM). AVL-3288 exhibits cognitive-enhancing properties in rodent models; displays no cytotoxic effects in PC12 cells or rat primary cortical neurons.
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