Bomedemstat New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP45548CAS No. ：1990504-34-1Purity：98%

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CAS No.	1990504-34-1	Cat. No.	BCP45548
Related Products	1990504-72-7（Bomedemstat ditosylate）
Name	Bomedemstat
Synonyms	IMG-7289; IMG 7289; IMG7289;
SMILES	CN1CCN(CC1)C(=O)C(CCCNC2CC2C3=CC=C(C=C3)F)NC(=O)C4=CC=C(C=C4)N5C=CN=N5
Chemical Name
Formula	C28H34FN7O2	M. Wt	519.61
Purity	98%	Storage	Store at 4-8°C
Description	Bomedemstat is an orally available, irreversible inhibitor of lysine-specific demethylase 1 (LSD1), with potential antineoplastic activity. Upon administration, bomedemstat binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the di- and mono-methylated forms of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor suppressor genes. In addition, LSD1 demethylates mono- or di-methylated H3K9 which increases gene expression of tumor promoting genes; thus, inhibition of LSD1 also promotes H3K9 methylation and decreases transcription of these genes. Altogether, this may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. LSD1, an enzyme belonging to the flavin adenine dinucleotide (FAD)-dependent amine oxidase family is overexpressed in certain tumor cells and plays a key role in the regulation of gene expression, tumor cell growth and survival.