AT-511 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1998705-64-8 | Cat. No. | BCP43134 |
| Name | AT-511 | ||
| Synonyms | AT511; AT 511; Bemnifosbuvir; | ||
| SMILES | CC(C)OC(=O)C(C)NP(=O)(OCC1C(C(C(O1)N2C=NC3=C(N=C(N=C32)N)NC)(C)F)O)OC4=CC=CC=C4 | ||
| Chemical Name | |||
| Formula | C24H33FN7O7P | M. Wt | 581.53 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AT-511, the free base form of AT-527, against several coronaviruses, including SARS-CoV-2, the causative agent of COVID-19. In normal human airway epithelial (HAE) cell preparations, the average concentration of AT-511 required to inhibit replication of SARS-CoV-2 by 90% (EC90) was 0.5 µM, very similar to the EC90 for AT-511 against HCoV-229E, HCoVOC43 and SARS-CoV in Huh-7 cells. No cytotoxicity was observed for AT-511 in any of the antiviral assays up to the highest concentration tested (100 µM). Surprisingly, AT-511 was 30-fold less active against MERS-CoV. | ||
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