eIF4A3-IN-1 New
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| CAS No. | 2095486-67-0 | Cat. No. | BCP45171 |
| Name | eIF4A3-IN-1 | ||
| Synonyms | |||
| SMILES | CC1=C(C=NN1C2=CC=CC(=C2)C#N)C(=O)N3CCN(C(C3)C4=CC=C(C=C4)Cl)C(=O)C5=CC=C(C=C5)Br | ||
| Chemical Name | |||
| Formula | C29H23BrClN5O2 | M. Wt | 588.88 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | eIF4A3-IN-1 is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD. | ||
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