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Imatinib mesylate Chemical Structure

Imatinib mesylate

Cat. No. :BCP01255CAS No. :220127-57-1Purity:98%
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Synonyms STI-571
CAS Number 220127-57-1
Purity 98%
M. Wt 589.71
Formula C29H31N7O.CH4O3S
Storage Store at -20°C
In vitro assays for inhibition of a panel of tyrosine and serine/threonine protein kinases show that Imatinib inhibits the v-Abl tyrosine kinase and PDGFR potently with an IC50 of 0.6 and 0.1 μM, respectively. Imatinib inhibits the SLF-dependent activation of wild-type c-kit kinase activity with a IC50 for these effects of approximately 0.1 μM, which is similar to the concentration required for inhibition of PDGFR. Imatinib exhibits growth-inhibitory activity on the human bronchial carcinoid ce

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