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Silatecan Chemical Structure

Silatecan

Cat. No. :BCP19768CAS No. :220913-32-6Purity:98%
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Synonyms AR67; AR 67; AR67; DB67; DB 67; DB67
CAS Number 220913-32-6
Purity 98%
M. Wt 478.61
Formula C26H30N2O5Si
Storage Store at 4-8°C
Silatecan (AR-67) is a synthetic, highly lipophilic derivative of camptothecin, with potential antineoplastic and radiosensitizing activities. Silatecan DB-67 binds to and stabilizes the topoisomerase I-DNA covalent complex, inhibiting the religation of topoisomerase I-mediated single-stranded DNA breaks and producing lethal double-stranded DNA breaks when encountered by the DNA replication machinery; inhibition of DNA replication and apoptosis follow. Camptothecin readily undergoes hydrolysis at physiological pH, changing its conformation from the active lactone structure to an inactive carboxylate form.

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