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Silatecan Chemical Structure

Silatecan

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP19768CAS No. ：220913-32-6Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 220913-32-6 Cat. No. BCP19768
Name Silatecan
Synonyms AR67; AR 67; AR67; DB67; DB 67; DB67;
SMILES CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C5=C(C=CC(=C5)O)N=C4C3=C2)[Si](C)(C)C(C)(C)C)O
Chemical Name
Formula C26H30N2O5Si M. Wt 478.61
Purity 98% Storage Store at 4-8°C
Description Silatecan (AR-67) is a synthetic, highly lipophilic derivative of camptothecin, with potential antineoplastic and radiosensitizing activities. Silatecan DB-67 binds to and stabilizes the topoisomerase I-DNA covalent complex, inhibiting the religation of topoisomerase I-mediated single-stranded DNA breaks and producing lethal double-stranded DNA breaks when encountered by the DNA replication machinery; inhibition of DNA replication and apoptosis follow. Camptothecin readily undergoes hydrolysis at physiological pH, changing its conformation from the active lactone structure to an inactive carboxylate form.
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