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ZK824859 Chemical Structure

ZK824859

Data Sheet For research use only. Not for human use.
Cat. No. :BCP30356CAS No. :2254001-81-3Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 2254001-81-3 Cat. No. BCP30356
Name ZK824859
Synonyms ZK-824859; ZK 824859;2271122-53-1;
SMILES CC[C@@H](OC1=NC(OC2=CC(C3=CC=CC(CN)=C3)=CC(C)=C2)=C(F)C=C1F)C(O)=O
Chemical Name
Formula C23H22F2N2O4 M. Wt 428.44
Purity 98% Storage Store at 4-8°C
Description ZK824859 (ZK-824859) is a potent, selective urokinase plasminogen activator (uPA) inhibitor with IC50 of 79 nM (human uPA), displays little to no inhibitory activity against tPA and Plasmin (IC50>1 uM); ZK 824859 is 5 fold less potent and has lost selectivity in mouse: uPA IC50=410 nM; tPA IC50=910 nM; plasmin IC50=1600 nM; demonstrates efficacy in either acute or chronic mouse EAE models.
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