SGK3 degrader-1 New
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| CAS No. | 2381320-35-8 | Cat. No. | BCP35166 |
| Name | SGK3 degrader-1 | ||
| Synonyms | PROTAC SGK3 degrader-1;SGK3-PROTAC1; | ||
| SMILES | FC1=C(C=C(C=C1)C)S(=O)(NC2=CC=C(C=C2)C3=NC4=C(C(OC[C@H]5CN(CCO5)CCCCCCOCCOCCOCC(N[C@H](C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C=C7)C8=C(N=CS8)C)=O)=O)C(C)(C)C)=O)=N3)C=NN4)=O | ||
| Chemical Name | |||
| Formula | C57H73FN10O11S2 | M. Wt | 1157.38 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SGK3 degrader-1 is a potent SGK3 degrader based on PROTAC. PROTAC SGK3 degrader-1 (0.3 μM) induces 50% degradation of endogenous SGK3 within 2 hours, with maximal 80% degradation observed within 8 hours, accompanied by a loss of phosphorylation of NDRG1 (an SGK3 substrate). | ||
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