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Pritelivir Chemical Structure

Pritelivir

Data Sheet For research use only. Not for human use.
Cat. No. :BCP08742CAS No. :348086-71-5Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 348086-71-5 Cat. No. BCP08742
Name Pritelivir
Synonyms BAY57-1293; BAY 57-1293; BAY-57-1293; BAY571293; BAY 571293; BAY-571293; AIC-316; AIC 316; AIC316;
SMILES
Chemical Name
Formula C18H18N4O3S2 M. Wt 402.49
Purity 98% Storage Store at 4-8°C
Description Pritelivir is a potent helicase primase inhibitor. BAY 57-1293 inhibits replication of herpes simplex virus (HSV) type 1 and type 2 in the nanomolar range in vitro by abrogating the enzymatic activity of the viral primase-helicase complex. In various rodent models of HSV infection the antiviral activity of BAY 57-1293 in vivo was found to be superior compared to all compounds currently used to treat HSV infections. The compound shows profound antiviral activity in murine and rat lethal challenge models of disseminated herpes, in a murine zosteriform spread model of cutaneous disease, and in a murine ocular herpes model. It is active in parenteral, oral, and topical formulations.
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