Ganciclovir

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP12705CAS No. ：82410-32-0Purity：98%

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CAS No.	82410-32-0	Cat. No.	BCP12705
Name	Ganciclovir
Synonyms	2-Amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6H-purin-6-one; 9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)-methyl)guanine; 9-(1,3-Dihydroxy-2-propoxymethyl)guanine; 2;
SMILES
Chemical Name
Formula	C9H13N5O4	M. Wt	255.23
Purity	98%	Storage	Store at 4-8°C
Description	Ganciclovir is metabolized to the triphosphate form by primarily three cellular enzymes: (1) a deoxyguanosine kinase induced by CMV-infected cells; (2) guanylate kinase; and (3) phosphoglycerate kinase.Ganciclovir is sufficient to induce cell death in most bystander cells cocultured with HSV-tk-expressing cells. Ganciclovir significantly reduces DNA synthesis in the transformed cells, whereas Ganciclovir has little effect on DNA synthesis in the nontransformed cells. Ganciclovir exhibits a concentration-dependent reduction in the rate of elongation into mature DNA. Ganciclovir induces cell cycle arrests rather than direct chemical effect on HSVtk-transduced B16F10 melanoma cells. Ganciclovir produces only weak inhibition of DNA synthesis. Ganciclovir-treated cells accumulate in early S-phase and remained there until cell death, suggesting that ganciclovir incorporation in the DNA template is important for cytotoxicity. Ganciclovir-induced apoptosis is due to incorporation of the drug i