Pazopanib
Data Sheet
For research use only. Not for human use.
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| CAS No. | 444731-52-6 | Cat. No. | BCP01839 |
| Related Products | 635702-64-6（Pazopanib HCl） | ||
| Name | Pazopanib | ||
| Synonyms | GW 786034;GW-786034;GW786034; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C21H23N7O2S | M. Wt | 437.53 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Pazopanib potently inhibits VEGF-induced phosphorylation of VEGFR2 in HUVEC cells with IC50 of 8 nM.PPazopanib shows dose-dependent growth inhibition in all synovial sarcoma cell lines including SYO-1 and HS-SY-II cells. Proliferation of SYO-1 and HS-SY-II cells is inhibited even at 1?μg/mL of Pazopanib and is completely abolished at 5?μg/mL. Pazopanib induces G1 arrest, and thereby suppresses the growth of synovial sarcoma cells. Phosphorylation of Akts, GSK-3β, JNKs, p70 S6 Kinase, and mTOR is suppressed in Pazopanib-treated SYO-1 cells compared with that in the vehicle-treated cells. Pazopanib between 20 m g/mL and 22.5 m g/mL shows an increasing reduction of RPE cell viability. | ||
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