Fludrocortisone acetate New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 514-36-3 | Cat. No. | BCP38927 |
| Name | Fludrocortisone acetate | ||
| Synonyms | Fludrocortisone 21-acetate; | ||
| SMILES | CC(=O)OCC(=O)C1(CCC2C1(CC(C3(C2CCC4=CC(=O)CCC43C)F)O)C)O | ||
| Chemical Name | |||
| Formula | C23H31FO6 | M. Wt | 422.49 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Fludrocortisone Acetate is the acetate salt of a synthetic fluorinated corticosteroid with antiinflammatory and antiallergic activities. As a glucocorticoid-receptor agonist, fludrocortisone binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na+ reabsorption and water retention and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney. | ||
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