STO-609

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP25514CAS No. ：52029-86-4Purity：98%

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CAS No.	52029-86-4	Cat. No.	BCP25514
Name	STO-609
Synonyms	STO609 ;STO 609;
SMILES	O=C(C1=C2C3=C(C4=NC5=CC=CC=C5N4C(C3=CC=C2)=O)C=C1)O
Chemical Name
Formula	C19H10N2O3	M. Wt	314.29
Purity	98%	Storage	Store at 4-8°C
Description	STO-609 is a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. STO-609 inhibits the activities of recombinant CaM-KK alpha and CaM-KK beta isoforms, with K(i) values of 80 and 15 ng/ml, respectively, and also inhibits their autophosphorylation activities. STO-609 is highly selective for CaM-KK without any significant effect on the downstream CaM kinases (CaM-KI and -IV), and the IC(50) value of the compound against CaM-KII is approximately 10 microg/ml. STO-609 is a selective and cell-permeable inhibitor of CaM-KK and that it may be a useful tool for evaluating the physiological significance of the CaM-KK-mediated pathway in vivo as well as in vitro.