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Wedelolactone Chemical Structure

Wedelolactone

Cat. No. :BCP19859CAS No. :524-12-9Purity:98%
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Synonyms
CAS Number 524-12-9
Purity 98%
M. Wt 314.25
Formula C16H10O7
Storage Store at 4-8°C
Wedelolactone is a potent Î2-arrestin-biased G protein-coupled receptor-35 (GPR35) agonist, GPR35 has been shown to be a target of the asthma drugs cromolyn disodium and nedocromil sodium. Wedelolactone has anti-inflammatory, growth inhibitory, anti-cancer, anti-fibrotic, and pro-apoptotic effects. Wedelolactone stimulates ER genomic and non-genomic signalling pathways; it can significantly inhibit the activation of LX-2 cells, the underlying mechanisms of which included inducing Bcl-2 family involved apoptosis, up-regulating phosphorylated status of ERK and JNK expressions, and inhibiting NF-κB mediated activity.

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