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Wedelolactone Chemical Structure

Wedelolactone

Data Sheet For research use only. Not for human use.
Cat. No. :BCP19859CAS No. :524-12-9Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 524-12-9 Cat. No. BCP19859
Name Wedelolactone
Synonyms
SMILES
Chemical Name
Formula C16H10O7 M. Wt 314.25
Purity 98% Storage Store at 4-8°C
Description Wedelolactone is a potent Î2-arrestin-biased G protein-coupled receptor-35 (GPR35) agonist, GPR35 has been shown to be a target of the asthma drugs cromolyn disodium and nedocromil sodium. Wedelolactone has anti-inflammatory, growth inhibitory, anti-cancer, anti-fibrotic, and pro-apoptotic effects. Wedelolactone stimulates ER genomic and non-genomic signalling pathways; it can significantly inhibit the activation of LX-2 cells, the underlying mechanisms of which included inducing Bcl-2 family involved apoptosis, up-regulating phosphorylated status of ERK and JNK expressions, and inhibiting NF-κB mediated activity.
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