LY2409881 trihydrochloride
Data Sheet
For research use only. Not for human use.
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| CAS No. | 946518-60-1 | Cat. No. | BCP16149 |
| Name | LY2409881 trihydrochloride | ||
| Synonyms | LY-2409881 trihydrochloride;LY 2409881 trihydrochloride; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C24H32Cl4N6OS | M. Wt | 594.43 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | in vitro: LY2409881 inhibited constitutively activated NF-κB, and caused concentration- and time-dependent growth inhibition and apoptosis in lymphoma cells. Pretreatment of LY10 with 10 umol/L of LY2409881 prevented the formation of phosphorylated IkB in samples treated with TNFa for 2, 20, and 60 minutes in the presence of abundant IkB protein. in vivo: LY2409881 was safe to mice at three dose levels, 50, 100, and 200 mg/kg, all of which caused significant inhibition of tumor growth. LY2409881 suppressed the activity of the NF-κB subunit p65 in lymphoma cells treated by the HDAC inhibitor romidepsin, underlying a potential mechanism of the marked synergy observed of these two drugs. | ||
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