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(−)-Nutlin-3 Chemical Structure

(−)-Nutlin-3

Cat. No. :BCP29278CAS No. :548472-68-0Purity:98%
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Synonyms 4-{[(4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazol-1-yl]carbonyl}-2-piperazinone
CAS Number 548472-68-0
Purity 98%
M. Wt 581.49
Formula C30H30Cl2N4O4
Storage Store at 4-8°C
Nutlin 3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM in a cell-free assay; stabilizes p73 in p53-deficient cells.

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