Home   >  
Cell Cycle/DNA Damage
  >  
Topoisomerase
  >   Aclarubicin
Aclarubicin Chemical Structure

Aclarubicin

Cat. No. :BCP21845CAS No. :57576-44-0Purity:98%
Real-Time Inquiry ×

* Required Fields.

Please complete the form below and you will get the price list in 1 minute.

Product name

 

* Applicant name

Catalog Number

 

* Institution/Company

* Email address

 

Phone number

Country

 

* Quantity Required

Remarks

Inquiry Online ×

* Required Fields.

Please complete the form below and we will contact you shortly.

Product name

 

* Applicant name

Catalog Number

 

* Institution/Company

* Email address

 

Phone number

Country

 

* Quantity Required

Remarks

Bulk Inquiry ×

* Required Fields.

Please complete the form below and we will contact you shortly.

Product name

 

* Applicant name

Catalog Number

 

* Institution/Company

* Email address

 

Phone number

Country

 

* Quantity Required

Remarks

  • Information
  • Introduction
  • Quality Control
Synonyms Aclacinomycin A;Jaclacin
CAS Number 57576-44-0
Purity 98%
M. Wt 811.87
Formula C42H53NO15
Storage Store at 4-8°C
Aclacinomycin A is a dual inhibitor of topoisomerase I and II. Aclacinomycin A is an anticancer drug which can reduce the tumor with minimal damage to normal cells. Aclacinomycin A shows potency against a wide variety of solid tumours and haematological malignancies. In A549, HepG2 and MCF-7 cells, Aclacinomycin A shows cytotoxic activity with IC50 values of 0.27μM, 0.32μM and 0.62μM, respectively. Aclacinomycin A induces cell apoptosis in these cells and the effects change to be necrosis when the incubation time is prolonged. Aclacinomycin A is demonstrated to increase the activity of both caspase-3 and caspase-8, thus inducing the activation of PARP. Apart from that, as an inhibitor of opoisomerases, Aclacinomycin A is found to induce DNA damage in V79 and irs-2 cells. Aclacinomycin A is used to treat acute leukaemias, lymphomas and other solid tumors through its inhibition of topo II.

Tags:Aclarubicin supplier,Aclarubicin purchase,Aclarubicin manufacturer,Aclarubicin distributor,Aclarubicin cost,Aclarubicin buy,Aclarubicin for sale

0086-15971444841