Aclarubicin

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP21845CAS No. ：57576-44-0Purity：98%

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CAS No.	57576-44-0	Cat. No.	BCP21845
Name	Aclarubicin
Synonyms	Aclacinomycin A；Jaclacin;
SMILES	CCC1(CC(C2=C(C1C(=O)OC)C=C3C(=C2O)C(=O)C4=C(C3=O)C=CC=C4O)OC5CC(C(C(O5)C)OC6CC(C(C(O6)C)OC7CCC(=O)C(O7)C)O)N(C)C)O
Chemical Name
Formula	C42H53NO15	M. Wt	811.87
Purity	98%	Storage	Store at 4-8°C
Description	Aclacinomycin A is a dual inhibitor of topoisomerase I and II. Aclacinomycin A is an anticancer drug which can reduce the tumor with minimal damage to normal cells. Aclacinomycin A shows potency against a wide variety of solid tumours and haematological malignancies. In A549, HepG2 and MCF-7 cells, Aclacinomycin A shows cytotoxic activity with IC50 values of 0.27μM, 0.32μM and 0.62μM, respectively. Aclacinomycin A induces cell apoptosis in these cells and the effects change to be necrosis when the incubation time is prolonged. Aclacinomycin A is demonstrated to increase the activity of both caspase-3 and caspase-8, thus inducing the activation of PARP. Apart from that, as an inhibitor of opoisomerases, Aclacinomycin A is found to induce DNA damage in V79 and irs-2 cells. Aclacinomycin A is used to treat acute leukaemias, lymphomas and other solid tumors through its inhibition of topo II.