Fluvoxamine maleate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 61718-82-9 | Cat. No. | BCP06470 |
| Name | Fluvoxamine maleate | ||
| Synonyms | MK-264;MK264;MK 264; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C19H25F3N2O6 | M. Wt | 434.41 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Fluvoxamine (maleate) is the maleate salt form of fluvoxamine, which is effective in inhibiting 5-HT uptake by blood platelets and brain synaptosomes. The antagonism by fluvoxamine of the reserpine-induced lowering of the pentamethylenetetrazole convulsive threshold can be regarded as due to an effect upon 5-HT uptake. In contrast to the effects of desmethylimipramine and imipramine, no stimulatory effects are found in rats when rapidly acting reserpine-like compounds are given following a dose of fluvoxamine . fluvoxamine appears to improve combat-related PTSD symptoms but not depressive symptoms. The high attrition rate and lack of a placebo group limits the conclusions of our study. Controlled studies of fluvoxamine in the treatment of PTSD are warranted. Fluvoxamine was less potent at decreasing ethanol self-administration when food was available concurrently versus when ethanol was available in isolation [ED50: 4.0 (2.7-5.9) and 5.1 (4.3-6.0)]. Effects on food were similar under e | ||
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