Leuprorelin acetate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 74381-53-6 | Cat. No. | BCP02071 |
| Name | Leuprorelin acetate | ||
| Synonyms | Leuprorelin acetate; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C59H84N16O12.C2H4O2 | M. Wt | 1269.45 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | By interrupting the normal pulsatile stimulation of, and thus desensitizing, the GnRH receptors, it indirectly downregulates the secretion of gonadotropins luteinizing hormone and follicle-stimulating hormone, leading to hypogonadism and thus a dramatic reduction in estradiol andtestosterone levels in both sexes. in vitro: The number of DNA 3'-end-labeled cells/cm2 in leiomyomas of control patients and in leiomyomas at the 2nd, 8th, 12th, and 16th weeks of Leuprolide Acetate treatment were at low levels. Testosterone, estradiol and progesterone were also reduced by LA, even though this reduction occurred for progesterone only at the highest LA dosage (10(-6)M; 606.0+/-114.3 ng/ml versus 1524.0+/-246.5 ng/ml; p=0.02). in vivo: Leuprolide acetate treatment decreases the severity of clinical signs of locomotion, induces a significantly greater body weight gain, increases the MBP and NFs expression, axonal area and cell infiltration in EAE animals. Leuprolide (200 and 300 microg kg(-1) s.c | ||
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