Flupirtine maleate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 75507-68-5 | Cat. No. | BCP02202 |
| Name | Flupirtine maleate | ||
| Synonyms | D 9998;D-9998;D9998;Katadolon;Keiton; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C19H21N4O6F | M. Wt | 420.4 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Flupirtine pre-incubated for 2 hours prevents cell death in rat cortical neurons induced by NMDA and gp120 of HIV-1. Flupirtine is capable of protecting primary neurons against glutamate-induced cytotoxicity by reducing calcium ion concentrations at 1-10 mM. Flupirtine pretreated for 2 hours preventsβ-amyloid-induced apoptosis in primary neuronal cells at concentrations of 1 or 5μg/mL. Flupirtine at concentration of 10 μM markedly decreases nonreceptor-mediated necrotic cell death in PC 12 cultures treated with 10 mM L-glutamate, meanwhile, Flupirtine exerts anti-oxidative effects in PC 12 cultures. Flupirtine-maleate at concentrations of 1 μM and 10 μM decreases TRAIL-mediated death of human living brain tissue culture. Flupirtine activates inwardly rectifying potassium ion channels and thus stabilizes the resting membrane potential at a therapeutically relevant concentration. | ||
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