17-AAG

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01735CAS No. ：75747-14-7Purity：98%

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CAS No.	75747-14-7	Cat. No.	BCP01735
Name	17-AAG
Synonyms	KOS 953;NSC 330507;Tanespimycin;CP 127374;BMS 722782;
SMILES
Chemical Name
Formula	C31H43N3O8	M. Wt	585.69
Purity	98%	Storage	Store at 4-8°C
Description	17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC50 of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants.