WAY-204688 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP46376CAS No. ：796854-35-8Purity：98%

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CAS No.	796854-35-8	Cat. No.	BCP46376
Name	WAY-204688
Synonyms	SIM-688; SIM 688; SIM688; WAY-204688; WAY 204688;
SMILES	CC(C#N)(C(C1=CC=CC=C1OC)C2=CC=CC3=CC=CC=C32)C(=O)N4CCC(CC4)C5=CC(=CC=C5)C(F)(F)F
Chemical Name
Formula	C34H31F3N2O2	M. Wt	556.63
Purity	98%	Storage	Store at 4-8°C
Description	WAY-204688, also known as SIM-688, is an estrogen receptor agonist and NF-κB inhibitor potentially for the treatment of rheumatoid arthritis. Preservation of mucosal weight and prevention of histopathologic changes were observed with the administration of WAY-204688. Similar findings were observed in a cecal ligation and puncture model with WAY-204688 and a related compound WAY-169916. These results indicate that oral administration of these pathway-selective ER ligands preserved gastrointestinal barrier function and improve outcome in experimental models of systemic infection and inflammation. These agents may prove to be useful clinically as a novel treatment strategy for severe sepsis.