Way255348
Data Sheet
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| CAS No. | 872141-23-6 | Cat. No. | BCP21063 |
| Name | Way255348 | ||
| Synonyms | WAY-255348; WAY 255348; | ||
| SMILES | N#CC1=CC=C(C2=CC3=C(NC(C3(C)C)=O)C(F)=C2)N1C | ||
| Chemical Name | |||
| Formula | C16H14FN3O | M. Wt | 283.3 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | WAY-255348 is a potent nonsteroidal progesterone receptor (PR) antagonist. WAY-255348 inhibits the activity of progesterone. WAY-255348 achieves antagonist activity by binding to and subsequently preventing progesterone-induced nuclear accumulation, phosphorylation and promoter interactions of the PR. WAY-255348 bound PR conformation was similar to that of a progesterone agonist-bound PR and distinct from steroidal antagonist-bound PR conformations. WAY-255348 inhibits PR action through a novel molecular mechanism that is distinct from previously studied PR modulators and may be a useful tool to further understanding of PR signaling pathways. | ||
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