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XL-228 Chemical Structure

XL-228

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP08143CAS No. ：898280-07-4Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 898280-07-4 Cat. No. BCP08143
Name XL-228
Synonyms XL228;XL 228;
SMILES
Chemical Name
Formula C22H31N9O M. Wt 437.54
Purity 98% Storage Store at 4-8°C
Description Approximately 30% of the lines demonstrated XL228 IC50 values of <100nM in viability assays, including many lines with characterized ALK or FGFR mutations or amplifications. Cell lines showing the highest level of response to XL228 were often sensitive to other Aurora, ALK or FGFR inhibitors as well. Sub-20nM activity was demonstrated against FGFR2 in a cellular kinase ELISA assay, and confirmed by immunoblot analysis. Potency against ALK in the cell kinase assay was lower (approximately200 nM)
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