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BLZ945 Chemical Structure

BLZ945

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP14029CAS No. ：953769-46-5Purity：95%
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  • Chemical Properties&Biological Activity
CAS No. 953769-46-5 Cat. No. BCP14029
Name BLZ945
Synonyms BLZ 945; BLZ-945;Sotuletinib;
SMILES O=C(C1=NC=CC(OC2=CC=C3N=C(N[C@]4[C@](O)CCCC4)SC3=C2)=C1)NC
Chemical Name
Formula C20H22N4O3S M. Wt 398.48
Purity 95% Storage Store at 4-8°C
Description BLZ945 is a potent and selective CSF-1R kinase inhibitor. BLZ945 showed effects of CSF1R inhibition on other tumor-infiltrating immune cells. BLZ945 attenuates the turnover rate of TAMs while increasing the number of CD8+ T cells that infiltrate cervical and breast carcinomas. BLZ945 decreases the growth of malignant cells in the mouse mammary tumor virus-driven polyomavirus middle T antigen (MMTV-PyMT) model of mammary carcinogenesis. BLZ945 prevents tumor progression in the keratin 14-expressing human papillomavirus type 16 (K14-HPV-16) transgenic model of cervical carcinogenesis.
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H-NMR HPLC
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