Duloxetine

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP13463CAS No. ：116539-59-4Purity：98%

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CAS No.	116539-59-4	Cat. No.	BCP13463
Related Products	136434-34-9（Duloxetine HCl） 116817-11-9（(RS)-Duloxetine hydrochloride） 116539-60-7（(R)-Duloxetine）
Name	Duloxetine
Synonyms	(S)-Duloxetine;LY248686;LY-248686;LY 248686;
SMILES
Chemical Name
Formula	C18H19NOS	M. Wt	297.41
Purity	98%	Storage	Store at 4-8°C
Description	Duloxetine inhibits the reuptake of serotonin and norepinephrine in the central nervous system. Duloxetine is also considered a less potent inhibitor of dopamine reuptake. However, duloxetine has no significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and GABA receptors and can therefore be considered to be a selective reuptake inhibitor at the 5-HT and NA transporters. Duloxetine undergoes extensive metabolism, but the major circulating metabolites do not contribute significantly to the pharmacologic activity. Major depressive disorder is believed to be due in part to an increase in pro-inflammatory cytokines within the central nervous system. Antidepressants including ones with a similar mechanism of action as duloxetine, i.e. serotonin metabolism inhibition, cause a decrease in proinflammatory cytokine activity and an increase in anti-inflammatory cytokines; this mechanism may apply to duloxetine in its effect on depression but research o