XE 991 New
Data Sheet
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| CAS No. | 122955-42-4 | Cat. No. | BCP39201 |
| Name | XE 991 | ||
| Synonyms | XE991; XE-991; LS 190926; LS190926; LS-190926; | ||
| SMILES | C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3C2(CC4=CC=NC=C4)CC5=CC=NC=C5.Cl.Cl | ||
| Chemical Name | |||
| Formula | C26H20N2O | M. Wt | 376.45 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | XE 991 is a potent and selective blocker of KV7 (KCNQ) voltage-gated potassium channels. XE 991 blocks KV7.2+7.3 (KCNQ2+3) / M-currents (IC50 = 0.6 - 0.98 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 μM) but is less potent against KV7.1/minK channels (IC50 = 11.1 μM). XE 991 increases hippocampal ACh release and enhances cognition following oral administration in vivo, suggesting to be beneficial for Alzheimer's disease therapy. | ||
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