Vernakalant hydrochloride New
Data Sheet
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| CAS No. | 748810-28-8 | Cat. No. | BCP45728 |
| Name | Vernakalant hydrochloride | ||
| Synonyms | Vernakalant HCl;RSD1235 hydrochloride; | ||
| SMILES | COC1=C(C=C(C=C1)CCOC2CCCCC2N3CCC(C3)O)OC.Cl | ||
| Chemical Name | |||
| Formula | C20H32ClNO4 | M. Wt | 385.93 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Vernakalant HCl is an investigational drug for the acute conversion of atrial fibrillation. Like other class III antiarrhythmics, vernakalant blocks atrial potassium channels, thereby prolonging repolarization. It differs from typical class III agents by blocking a certain type of potassium channel, the cardiac transient outward potassium current, with increased potency as the heart rate increases. This means that it is more effective at high heart rates, while other class III agents tend to lose effectiveness under these circumstances. It also slightly blocks the hERG potassium channel, leading to a prolonged QT interval. Vernakalant also blocks atrial sodium channels. | ||
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