MK-7145 New
Data Sheet
For research use only. Not for human use.
Get Quotation Now* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
* Required Fields.
Please complete the form below and we will contact you shortly.
* Required Fields.
Please complete the form below and we will contact you shortly.
| CAS No. | 1255204-84-2 | Cat. No. | BCP38355 |
| Name | MK-7145 | ||
| Synonyms | MK 7145; MK7145; | ||
| SMILES | CC1=C(C=CC2=C1COC2=O)C(CN3CCN(CC3)CC(C4=C(C5=C(C=C4)C(=O)OC5)C)O)O | ||
| Chemical Name | |||
| Formula | C26H30N2O6 | M. Wt | 466.53 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | MK-7145 is a potent, selective and orally active ROMK inhibitor for the treatment of hypertension and heart failure. MK-7145 is selective against other cardiac ion channels such as Cav1.2 and Nav1.5 (IC50 > 30 μM). MK-7145 was not a potent reversible inhibitor of human CYP3A4, CYP2C9, or CYP2D6 (IC50 > 50μM) and was not a time-dependent inhibitor of CYP3A4 at 10and 50 μM. MK-7145 caused dose-dependent lowering of blood pressure in a subchronic SHR model. MK-7145 is the first small molecule ROMK inhibitor to enter clinical development. | ||
Recommend Products
More >
-
-
-
Branaplam hydrochloride
Cat. No.：BCP48029
No.：1562338-39-9
Product Details -
-
-
Vernakalant hydrochloride
Cat. No.：BCP45728
No.：748810-28-8
Product Details -
Terfenadine
Cat. No.：BCP43974
No.：50679-08-8
Product Details -
-
NS8593 hydrochloride
Cat. No.：BCP41256
No.：875755-24-1
Product Details -
-
-
-
-
-
-
ICA-105574
Cat. No.：BCP38017
No.：316146-57-3
Product Details -
-
-
BMS-191011
Cat. No.：BCP37808
No.：202821-81-6
Product Details -
Tags:MK-7145 supplier,MK-7145 purchase,MK-7145 manufacturer,MK-7145 distributor,MK-7145 cost,MK-7145 buy,MK-7145 for sale