Nirogacestat New
Data Sheet
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| CAS No. | 1290543-63-3 | Cat. No. | BCP24479 |
| Name | Nirogacestat | ||
| Synonyms | PF-03084014; PF03084014; PF 03084014; PF-3084014; PF3084014; PF 3084014; | ||
| SMILES | CCCC(C(=O)NC1=CN(C=N1)C(C)(C)CNCC(C)(C)C)NC2CCC3=C(C2)C(=CC(=C3)F)F | ||
| Chemical Name | |||
| Formula | C27H41F2N5O | M. Wt | 489.64 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Nirogacestat is a selective gamma secretase (GS) inhibitor with potential antitumor activity. Nirogacestat binds to GS, blocking proteolytic activation of Notch receptors; Notch signaling pathway inhibition may follow, which may result in the induction of apoptosis in tumor cells that overexpress Notch. The integral membrane protein GS is a multi-subunit protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors, at residues within their transmembrane domains. Overexpression of the Notch signaling pathway has been correlated with increased tumor cell growth and survival. | ||
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