LY900009
Data Sheet
For research use only. Not for human use.
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| CAS No. | 209984-68-9 | Cat. No. | BCP27986 |
| Name | LY900009 | ||
| Synonyms | LY-900009; LY 900009; | ||
| SMILES | CC(C)C(C(=O)NC(C)C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)O | ||
| Chemical Name | |||
| Formula | C23H27N3O4 | M. Wt | 409.48 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein. LY900009 inhibited plasma levels of amyloid-β peptide in a dose-dependent manner with 80-90% inhibition observed in the 30- to 60-mg cohorts. LY900009 is an orally available GSI (Aβ: IC50= 10.9−12.1 nM; Notch: IC50 = 14.1 nM) that was developed as a candidate therapeutic drug against AD (IDENTITY trial), which failed in phase III trials. | ||
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