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Tubastatin A hydrochloride Chemical Structure

Tubastatin A hydrochloride

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02887CAS No. :1310693-92-5Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1310693-92-5 Cat. No. BCP02887
Name Tubastatin A hydrochloride
Synonyms Tubastatin A HCl;TSA HCl;
SMILES
Chemical Name
Formula C20H21N3O2.HCl M. Wt 371.86
Purity 98% Storage Store at 4-8°C
Description Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s >16 μM), excluding HDAC8 (IC50 = 0.9 μM). Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.
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