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OTS-514 Chemical Structure

OTS-514

Cat. No. :BCP23870CAS No. :1338540-63-8Purity:98%
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Synonyms OTS514 ; OTS 514
CAS Number 1338540-63-8
Purity 98%
M. Wt 364.46
Formula C21H20N2O2S
Storage Store at 4-8°C
OTS514 is a potent TOPK (T-LAK cell-originated protein kinase) inhibitor. OTS514 exhibits growth suppressive effect on small cell lung cancer. TS514 effectively suppressed growth of SCLC cell lines (IC50 ; 0.4 ~ 42.6 nM) and led to their apoptotic cell death. Treatment with OTS514 suppressed forkhead box protein M1 (FOXM1) activity, which was involved in stemness of CSC. Furthermore, OTS514 treatment reduced CD90-positive SCLC cells and showed higher cytotoxic effect against lung sphere-derived CSC-like SCLC cells.

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