OTS-514
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1338540-63-8 | Cat. No. | BCP23870 |
| Name | OTS-514 | ||
| Synonyms | OTS514 ; OTS 514; | ||
| SMILES | O=C1NC2=C(C(C3=CC=C([C@@H](C)CN)C=C3)=C(O)C=C2C)C4=C1SC=C4 | ||
| Chemical Name | |||
| Formula | C21H20N2O2S | M. Wt | 364.46 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | OTS514 is a potent TOPK (T-LAK cell-originated protein kinase) inhibitor. OTS514 exhibits growth suppressive effect on small cell lung cancer. TS514 effectively suppressed growth of SCLC cell lines (IC50 ; 0.4 ~ 42.6 nM) and led to their apoptotic cell death. Treatment with OTS514 suppressed forkhead box protein M1 (FOXM1) activity, which was involved in stemness of CSC. Furthermore, OTS514 treatment reduced CD90-positive SCLC cells and showed higher cytotoxic effect against lung sphere-derived CSC-like SCLC cells. | ||
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