Fedratinib dihydrochloride hydrate New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1374744-69-0 | Cat. No. | BCP24783 |
| Name | Fedratinib dihydrochloride hydrate | ||
| Synonyms | TG-101348 hydrochloride hydrate; SAR 302503 hydrochloride hydrate;SAR302503; SAR-302503; SAR 302503; TG101348; TG-101348; TG 101348; | ||
| SMILES | CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4.O.Cl.Cl | ||
| Chemical Name | |||
| Formula | C27H40Cl2N6O4S | M. Wt | 615.62 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Fedratinib hydrochloride hydrate is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC50s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib hydrochloride hydrate shows 35- and 334-fold selectivity over JAK1 and JAK3, respectively. Fedratinib hydrochloride hydrate induces cancer cell apoptosis and has the potential for myeloproliferative disorders research. | ||
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