Elacridar New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP05709CAS No. ：143664-11-3Purity：98%

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CAS No.	143664-11-3	Cat. No.	BCP05709
Name	Elacridar
Synonyms	GF120918; GF-120918; GF 120918; GW 0918;GW-0918;GW0918; GG918;GG 918;GG-918; GF-120918; GF 120918;
SMILES
Chemical Name
Formula	C34H33N3O5	M. Wt	563.64
Purity	98%	Storage	Store at 4-8°C
Description	Elacridar is a P-glycoprotein (P-gp) inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. In vitro, GF120918A demonstrated high plasma protein binding across species, although a definitive protein binding evaluation was precluded by poor recovery, particularly in buffer and in mouse, rat, and dog plasma. GF120918A did not demonstrate potent inhibition of several human cytochrome P450 enzymes evaluated in vitro, with IC(50) values well above concentrations anticipated to be achieved in vivo. Together, these data confirm the utility of GF120918A as a tool P-glycoprotein inhibitor in preclinical species and offer additional guidance on preclinical dose regimens likely to produce P-glycoprotein-mediated effects.