ML792 New
Data Sheet
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| CAS No. | 1644342-14-2 | Cat. No. | BCP30807 |
| Name | ML792 | ||
| Synonyms | ML-792; ML 792; | ||
| SMILES | C1C(CC(C1COS(=O)(=O)N)O)NC2=NC=NC=C2C(=O)C3=NN(C=C3)CC4=CC(=CC=C4)Br | ||
| Chemical Name | |||
| Formula | C21H23BrN6O5S | M. Wt | 551.42 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | ML-792 is a potent and selective SAE inhibitor with nanomolar potency in cellular assays. ML-792 selectively blocks SAE enzyme activity and total SUMOylation, thus decreasing cancer cell proliferation. Moreover, Induction of the MYC oncogene increased the ML-792-mediated viability effect in cancer cells, thus indicating a potential application of SAE inhibitors in treating MYC-amplified tumors. ML-792 provides rapid loss of endogenously SUMOylated proteins, thereby facilitating novel insights into SUMO biology. | ||
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