MeriMepodib
Data Sheet
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| CAS No. | 198821-22-6 | Cat. No. | BCP28336 |
| Name | MeriMepodib | ||
| Synonyms | VX497; VX-497; VX 497; MMP; VI21497; VI-21497; VI 21497; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C23H24N4O6 | M. Wt | 452.46 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Merimepodib, also known as VX-497, is orally bioavailable IMPDH inhibitor, which inhibits the proliferation of primary human, mouse, rat, and dog lymphocytes at concentrations of approximately 100 nM. In vivo, oral administration of VX-497 inhibits the primary IgM antibody response in a dose-dependent manner, with an ED(50) value of approximately 30-35 mg/kg in mice. Single daily dosing of VX-497 is observed to be as effective as twice-daily dosing in this model of immune activation. These studies demonstrate that VX-497 is a potent, specific, and reversible IMPDH inhibitor that selectively inhibits lymphocyte proliferation. | ||
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