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LY-3381916 Chemical Structure

LY-3381916

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP33269CAS No. ：2166616-75-5Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 2166616-75-5 Cat. No. BCP33269
Name LY-3381916
Synonyms LY 3381916; LY 3381916; IDO1-IN-5;
SMILES FC1=CC=C(C(N[C@H](C)C2=CC=C(N(C(C3CCOCC3)=O)CC4)C4=C2)=O)C=C1
Chemical Name
Formula C23H25FN2O3 M. Wt 396.46
Purity 98% Storage Store at 4-8°C
Description LY-3381916, also known as IDO1-IN-5, is a potent, selective and brain penetrated DO1 inhibitor. LY3381916 specifically targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation of the amino acid tryptophan into the immunosuppressive metabolite kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, LY3381916 restores and promotes the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, and T lymphocytes, and causes a reduction in tumor-associated regulatory T cells (Tregs).
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