SR-717 free acid New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2375420-34-9 | Cat. No. | BCP35922 |
| Name | SR-717 free acid | ||
| Synonyms | SR 717; SR717; | ||
| SMILES | O=C(C1=CC(F)=C(C=C1NC(C2=NN=C(C=C2)N3C=CN=C3)=O)F)O | ||
| Chemical Name | |||
| Formula | C15H9F2N5O3 | M. Wt | 345.26 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SR-717 is an agonist of stimulator of interferon genes STING for treating cancer. SR-717 demonstrates broad interspecies and interallelic specificity. SR-717 functions as a direct cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic that induces the same "closed" conformation of STING. SR-717 displayed antitumor activity; promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitated antigen cross-priming. SR-717 also induced the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. | ||
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