BI-0474 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2750570-55-7 | Cat. No. | BCP49602 |
| Name | BI-0474 | ||
| Synonyms | BI0474;BI 0474; | ||
| SMILES | CC1CN(CCN1C2=CC(=CC(=N2)C3=NOC(=N3)C4(CCCC5=C4C(=C(S5)N)C#N)C)N6CCN(CC6)C(=O)C=C)C | ||
| Chemical Name | |||
| Formula | C30H37N9O2S | M. Wt | 587.74 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. BI-0474 exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models. | ||
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