ML406 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 774589-47-8 | Cat. No. | BCP35591 |
| Name | ML406 | ||
| Synonyms | ML-406; ML 406; | ||
| SMILES | CC(=O)C1=CC=C(C=C1)N2CCN(CC2)C(=O)C3=CC4=C(C=C3)OCO4 | ||
| Chemical Name | |||
| Formula | C20H20N2O4 | M. Wt | 352.39 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | ML406 is an iInhibitor of aminotranferase BioA, the enzyme that catalyzes the second-to-last step of biotin synthesis in Mycobacterium tuberculosis (TB). ML406 has an IC50 of 155 nM and an EC50 of 9.3 μM with best cellular activity tested in a TB strain with limited biotin formation relative to wild type confirming mechanism of action. | ||
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