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Ulixertinib Chemical Structure

Ulixertinib

Cat. No. :BCP04232CAS No. :869886-67-9Purity:98%
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Synonyms 1956366-10-1; BVD-523; BVD 523; BVD523; VRT752271; VRT752271; VRT 752271;
CAS Number 869886-67-9
Purity 98%
M. Wt 433.33
Formula C21H22Cl2N4O2
Storage Store at 4-8°C
Ulixertinib, also known as BVD-523 and VRT752271, is an inhibitors of ERK protein kinase. Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis. Upon oral administration, BVD-523 inhibits both ERK 1 and 2, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival.

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